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The Corona strain in California is more contagious and deadly than the original virus


A new study revealed that the Corona virus strain, which was first found in California, is more contagious than the original virus strain, and is likely to be associated with severe complications and partly resistant to antibodies, according to what was published by the American "Insider" website.


Charles Chiu, an infectious disease physician and sequencing expert at the University of California, who led the study, told the Los Angeles Times: More data is needed before conclusions can be drawn about this new strain.


The California Corona strain consists of two slightly different forms of the virus, called B.1.427 and B.1.429. It is also called CAL.20C using another naming system. It was first discovered in California in July, and has now been detected throughout the United States and other countries, including Australia, Denmark, Mexico and Taiwan.


Qiu and colleagues examined 2,172 viral samples collected from 44 of California's 58 counties between September 1 and January 29. At the beginning of September, they had not found any case of the B.1.427 / B.1.429 virus. By late January, the new strain accounted for nearly a quarter of the cases in the sequence.


From the data, Chiu and colleagues estimated that the number of cases caused by the variable is now doubling every 18 days, the New York Times reported.


Bruce Walker, an immunologist and founding director of the Ragon Institute in Boston, told the Los Angeles Times that it was difficult to "separate" all of the different factors that contribute to the spread, including travel, holiday gatherings and dining out.


William Hanag, an epidemiologist at Harvard University, said: “I am increasingly convinced that this strain is more locally transmitted than others but there is no evidence to suggest that it is like B.1.1.7, a variant that was first identified in the UK and is now spreading throughout United State.


The California breed has a major mutation

 

The study authors identified some possibilities that explain why the variable first discovered in California, B.1.427 /B.1.429, is more contagious than the other variants in the state.


First, they found that there was twice the amount of virus in the nasal swabs of those infected with B.1.427 /B.1.429, compared to those who were not infected. This may mean that people with the variant carry more virus particles and are more likely to pass the virus to others.


Second, the California variant contains a mutation, called L452R, in the spiky protein - the part of the virus used to infect cells.


 The authors designed the Coronavirus with the L452R mutation, and found that it was able to infect human lung tissue at least 40% more easily than other types, and was three times more infectious.


Third, the scientists found that the antibodies that the body produces to fight infection work 50% less against B.1.427 /B.1.429 than the original variant of the Coronavirus The effect was less pronounced than the variant that was first discovered in South Africa, which reduced the effectiveness of Antibodies to one sixth of their usual levels.


If the antibodies work less, this may mean an increased risk of reinfection, and vaccines may be less effective.


However, the study found that the variant that was first discovered in California produced a similar response to the antibodies of the original coronavirus.


The researchers also said that the alternative may be more lethal, and the team studied 324 medical records from University of California hospitals and medical center, and found that those who carried the substitute were 4.8 times more likely to be admitted to intensive care and 11 times more likely to die, compared to those with other variants. .

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